MRNA vaccine: Difference between revisions
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Added “citation needed”: I’m certain they are easier and faster to develop, but I don’t have a good reference for it now. Tags: Visual edit Mobile edit Mobile web edit |
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Just like normal vaccines, RNA vaccines are intended to induce the production of [[Antibody|antibodies]] which will bind to potential [[Pathogen|pathogens]]. This is accomplished when the RNA from the vaccine (a [[messenger RNA]]) is delivered into [[Cell (biology)|cells]] in the body, which then produce [[Protein|proteins]] that resemble or are identical to proteins from the pathogen. These proteins are then used by the body’s [[adaptive immune system]] to produce antibodies against the pathogen, causing future protection from the pathogen.<ref>{{cite web |last1=Hubaud |first1=Alexis |title=RNA vaccines: a novel technology to prevent and treat disease |url=http://sitn.hms.harvard.edu/flash/2015/rna-vaccines-a-novel-technology-to-prevent-and-treat-disease/ |website=sitn.hms.harvard.edu |publisher=Harvard University |accessdate=17 February 2020}}</ref> |
Just like normal vaccines, RNA vaccines are intended to induce the production of [[Antibody|antibodies]] which will bind to potential [[Pathogen|pathogens]]. This is accomplished when the RNA from the vaccine (a [[messenger RNA]]) is delivered into [[Cell (biology)|cells]] in the body, which then produce [[Protein|proteins]] that resemble or are identical to proteins from the pathogen. These proteins are then used by the body’s [[adaptive immune system]] to produce antibodies against the pathogen, causing future protection from the pathogen.<ref>{{cite web |last1=Hubaud |first1=Alexis |title=RNA vaccines: a novel technology to prevent and treat disease |url=http://sitn.hms.harvard.edu/flash/2015/rna-vaccines-a-novel-technology-to-prevent-and-treat-disease/ |website=sitn.hms.harvard.edu |publisher=Harvard University |accessdate=17 February 2020}}</ref> |
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Since RNA vaccines are much faster to [[Oligonucleotide synthesis|synthesise]] and test than [[Vaccine#Types|traditional vaccines]] (which would either require mass production of pathogen proteins or the generation of an [[Attenuated vaccine|attenuated]] [[mutant]] of the pathogen), a number of RNA vaccines are under development to combat the [[2019–20 coronavirus pandemic]]<ref>{{Cite web|url=https://www.statnews.com/2020/03/19/an-updated-guide-to-the-coronavirus-drugs-and-vaccines-in-development/|title=An updated guide to the coronavirus drugs and vaccines in development|date=2020-03-19|website=STAT|language=en-US|access-date=2020-03-21}}</ref>. |
Since RNA vaccines are much faster to [[Oligonucleotide synthesis|synthesise]] and test than [[Vaccine#Types|traditional vaccines]] (which would either require mass production of pathogen proteins or the generation of an [[Attenuated vaccine|attenuated]] [[mutant]] of the pathogen){{Citation needed|date=March 2020}}, a number of RNA vaccines are under development to combat the [[2019–20 coronavirus pandemic]]<ref>{{Cite web|url=https://www.statnews.com/2020/03/19/an-updated-guide-to-the-coronavirus-drugs-and-vaccines-in-development/|title=An updated guide to the coronavirus drugs and vaccines in development|date=2020-03-19|website=STAT|language=en-US|access-date=2020-03-21}}</ref>. |
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==See also== |
==See also== |
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Revision as of 04:18, 21 March 2020
An RNA vaccine is a novel type of vaccine which is composed of the nucleic acid RNA, packaged within a vector such as lipid nanoparticles[1]. No RNA vaccines have yet been approved for medical use, though clinical trials are ongoing[2].
Just like normal vaccines, RNA vaccines are intended to induce the production of antibodies which will bind to potential pathogens. This is accomplished when the RNA from the vaccine (a messenger RNA) is delivered into cells in the body, which then produce proteins that resemble or are identical to proteins from the pathogen. These proteins are then used by the body’s adaptive immune system to produce antibodies against the pathogen, causing future protection from the pathogen.[3]
Since RNA vaccines are much faster to synthesise and test than traditional vaccines (which would either require mass production of pathogen proteins or the generation of an attenuated mutant of the pathogen)[citation needed], a number of RNA vaccines are under development to combat the 2019–20 coronavirus pandemic[4].
See also
References
- ^ "mRNA Platform". CureVac. Retrieved 2020-03-21.
{{cite web}}: CS1 maint: url-status (link) - ^ Zhang, Cuiling; Maruggi, Giulietta; Shan, Hu; Li, Junwei (2019). "Advances in mRNA Vaccines for Infectious Diseases". Frontiers in Immunology. 10. doi:10.3389/fimmu.2019.00594. ISSN 1664-3224.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Hubaud, Alexis. "RNA vaccines: a novel technology to prevent and treat disease". sitn.hms.harvard.edu. Harvard University. Retrieved 17 February 2020.
- ^ "An updated guide to the coronavirus drugs and vaccines in development". STAT. 2020-03-19. Retrieved 2020-03-21.