MEIS2: Difference between revisions
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{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{Infobox_gene}} |
{{Infobox_gene}} |
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'''Homeobox protein Meis2''' is a [[protein]] that in humans is encoded by the ''MEIS2'' [[gene]].<ref name="pmid9383298">{{cite journal |vauthors=Smith JE, Afonja O, Yee HT, Inghirami G, Takeshita K | title = Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene | journal = Mamm Genome | volume = 8 | issue = 12 | pages = 951–2 |date=Jan 1998 | pmid = 9383298 |
'''Homeobox protein Meis2''' is a [[protein]] that in humans is encoded by the ''MEIS2'' [[gene]].<ref name="pmid9383298">{{cite journal |vauthors=Smith JE, Afonja O, Yee HT, Inghirami G, Takeshita K | title = Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene | journal = Mamm Genome | volume = 8 | issue = 12 | pages = 951–2 |date=Jan 1998 | pmid = 9383298 | doi =10.1007/s003359900621 | s2cid = 20187903 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MEIS2 Meis homeobox 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4212}}</ref> |
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This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MEIS2 Meis homeobox 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4212 |
This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MEIS2 Meis homeobox 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4212}}</ref> |
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==References== |
==References== |
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==Further reading== |
==Further reading== |
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{{refbegin | 2}} |
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*{{cite journal |vauthors=Hui H, Perfetti R |title=Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood. |journal=Eur. J. Endocrinol. |volume=146 |issue= 2 |pages= 129–41 |year= 2002 |pmid= 11834421 |doi=10.1530/eje.0.1460129 }} |
*{{cite journal |vauthors=Hui H, Perfetti R |title=Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood. |journal=Eur. J. Endocrinol. |volume=146 |issue= 2 |pages= 129–41 |year= 2002 |pmid= 11834421 |doi=10.1530/eje.0.1460129 |doi-access=free }} |
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*{{cite journal |vauthors=Steelman S, Moskow JJ, Muzynski K, etal |title=Identification of a conserved family of Meis1-related homeobox genes. |journal=Genome Res. |volume=7 |issue= 2 |pages= 142–56 |year= 1997 |pmid= 9049632 |doi=10.1101/gr.7.2.142 }} |
*{{cite journal |vauthors=Steelman S, Moskow JJ, Muzynski K, etal |title=Identification of a conserved family of Meis1-related homeobox genes. |journal=Genome Res. |volume=7 |issue= 2 |pages= 142–56 |year= 1997 |pmid= 9049632 |doi=10.1101/gr.7.2.142 |doi-access=free }} |
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*{{cite journal |vauthors=Capdevila J, Tsukui T, Rodríquez Esteban C, etal |title=Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. |journal=Mol. Cell |volume=4 |issue= 5 |pages= 839–49 |year= 2000 |pmid= 10619030 |doi=10.1016/S1097-2765(00)80393-7 }} |
*{{cite journal |vauthors=Capdevila J, Tsukui T, Rodríquez Esteban C, etal |title=Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. |journal=Mol. Cell |volume=4 |issue= 5 |pages= 839–49 |year= 2000 |pmid= 10619030 |doi=10.1016/S1097-2765(00)80393-7 |doi-access=free }} |
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*{{cite journal |vauthors=Yang Y, Hwang CK, D'Souza UM, etal |title=Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20734–41 |year= 2000 |pmid= 10764806 |doi= 10.1074/jbc.M908382199 }} |
*{{cite journal |vauthors=Yang Y, Hwang CK, D'Souza UM, etal |title=Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20734–41 |year= 2000 |pmid= 10764806 |doi= 10.1074/jbc.M908382199 |doi-access= free }} |
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*{{cite journal |vauthors=Liu Y, MacDonald RJ, Swift GH |title=DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 17985–93 |year= 2001 |pmid= 11279116 |doi= 10.1074/jbc.M100678200 }} |
*{{cite journal |vauthors=Liu Y, MacDonald RJ, Swift GH |title=DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 17985–93 |year= 2001 |pmid= 11279116 |doi= 10.1074/jbc.M100678200 |doi-access= free }} |
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*{{cite journal |vauthors=Fujino T, Yamazaki Y, Largaespada DA, etal |title=Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes. |journal=Exp. Hematol. |volume=29 |issue= 7 |pages= 856–63 |year= 2001 |pmid= 11438208 |doi=10.1016/S0301-472X(01)00655-5 }} |
*{{cite journal |vauthors=Fujino T, Yamazaki Y, Largaespada DA, etal |title=Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes. |journal=Exp. Hematol. |volume=29 |issue= 7 |pages= 856–63 |year= 2001 |pmid= 11438208 |doi=10.1016/S0301-472X(01)00655-5 |doi-access=free }} |
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*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} |
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} |
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*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} |
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }} |
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*{{cite journal |vauthors=Dintilhac A, Bihan R, Guerrier D, etal |title=A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during embryogenesis. |journal=Gene Expr. Patterns |volume=4 |issue= 2 |pages= 215–22 |year= 2004 |pmid= 15161102 |doi= 10.1016/j.modgep.2003.08.006 }} |
*{{cite journal |vauthors=Dintilhac A, Bihan R, Guerrier D, etal |title=A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during embryogenesis. |journal=Gene Expr. Patterns |volume=4 |issue= 2 |pages= 215–22 |year= 2004 |pmid= 15161102 |doi= 10.1016/j.modgep.2003.08.006 }} |
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*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} |
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} |
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Latest revision as of 08:53, 12 August 2023
Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.[5][6]
This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.[6]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000134138 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027210 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Smith JE, Afonja O, Yee HT, Inghirami G, Takeshita K (Jan 1998). "Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene". Mamm Genome. 8 (12): 951–2. doi:10.1007/s003359900621. PMID 9383298. S2CID 20187903.
- ^ a b "Entrez Gene: MEIS2 Meis homeobox 2".
Further reading
[edit]- Hui H, Perfetti R (2002). "Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood". Eur. J. Endocrinol. 146 (2): 129–41. doi:10.1530/eje.0.1460129. PMID 11834421.
- Steelman S, Moskow JJ, Muzynski K, et al. (1997). "Identification of a conserved family of Meis1-related homeobox genes". Genome Res. 7 (2): 142–56. doi:10.1101/gr.7.2.142. PMID 9049632.
- Capdevila J, Tsukui T, Rodríquez Esteban C, et al. (2000). "Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin". Mol. Cell. 4 (5): 839–49. doi:10.1016/S1097-2765(00)80393-7. PMID 10619030.
- Yang Y, Hwang CK, D'Souza UM, et al. (2000). "Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription". J. Biol. Chem. 275 (27): 20734–41. doi:10.1074/jbc.M908382199. PMID 10764806.
- Liu Y, MacDonald RJ, Swift GH (2001). "DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex". J. Biol. Chem. 276 (21): 17985–93. doi:10.1074/jbc.M100678200. PMID 11279116.
- Fujino T, Yamazaki Y, Largaespada DA, et al. (2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes". Exp. Hematol. 29 (7): 856–63. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Dintilhac A, Bihan R, Guerrier D, et al. (2004). "A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during embryogenesis". Gene Expr. Patterns. 4 (2): 215–22. doi:10.1016/j.modgep.2003.08.006. PMID 15161102.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
External links
[edit]- MEIS2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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