Wikipedia:WikiProject Chemicals/Chembox validation/VerifiedDataSandbox and 2,3-Dihydroxy-3-methylpentanoic acid: Difference between pages
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Saving copy of the {{chembox}} taken from revid 444167483 of page 2,3-Dihydroxy-3-methylpentanoic_acid for the Chem/Drugbox validation project (updated: 'CASNo'). |
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{{ambox | text = This page contains a copy of the infobox ({{tl|chembox}}) taken from revid [{{fullurl:2,3-Dihydroxy-3-methylpentanoic_acid|oldid=444167483}} 444167483] of page [[2,3-Dihydroxy-3-methylpentanoic_acid]] with values updated to verified values.}} |
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{{chembox |
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| verifiedrevid = |
| verifiedrevid = 477198728 |
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|ImageFile=2,3-Dihydroxy-3-methylpentanoic acid. |
| ImageFile=2,3-Dihydroxy-3-methylpentanoic acid.svg |
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|ImageSize=180px |
| ImageSize=180px |
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| PIN=2,3-Dihydroxy-3-methylpentanoic acid |
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|OtherNames= |
| OtherNames= |
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|Section1={{Chembox Identifiers |
|Section1={{Chembox Identifiers |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 7 |
| ChemSpiderID = 7 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = PDGXJDXVGMHUIR-UHFFFAOYSA-N |
| StdInChIKey = PDGXJDXVGMHUIR-UHFFFAOYSA-N |
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| CASNo_Ref = {{cascite|changed|??}} |
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| CASNo = <!-- blanked - oldvalue: 562-43-6 --> |
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| CASNo=562-43-6 |
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| PubChem=8 |
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| SMILES=CCC(C)(C(C(=O)O)O)O |
| PubChem=8 |
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| SMILES=CCC(C)(C(C(=O)O)O)O |
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| MeSHName=2,3-dihydroxy-3-methylpentanoic+acid |
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|Section2={{Chembox Properties |
|Section2={{Chembox Properties |
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| Formula=C<sub>6</sub>H<sub>12</sub>O<sub>4</sub> |
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| MolarMass=148.16 g/mol |
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'''2,3-Dihydroxy-3-methylpentanoic acid''' is an intermediate in the metabolism of [[isoleucine]]. |
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== Metabolism == |
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2,3-Dihydroxy-3-methylpentanoate is synthesized by the action of [[acetolactate mutase]] with subsequent reduction from [[α-aceto-α-hydroxybutyrate]] through [[3-hydroxy-2-keto-3-methylpentanoate]]:<ref name=":0">{{Cite book |last=Voet |first=Donald |title=Biochemistry |last2=Voet |first2=Judith G. |date=2011 |publisher=Wiley |isbn=978-0-470-91745-9 |edition=4. |location=Hoboken, NJ |pages=1074{{--}}1075}}</ref> |
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: α-aceto-α-hydroxybutyrate → 3-hydroxy-2-keto-3-methylpentanoate |
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: 3-hydroxy-2-keto-3-methylpentanoate + NAD(P)H → 2,3-dihydroxy-3-methylpentanoate + NAD(P)<sup>+</sup> |
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It is then processed by the action of [[dihydroxyacid dehydratase]], which results in [[2-keto-3-methylvalerate]] and water:<ref name=":0" /> |
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: 2,3-dihydroxy-3-methylpentanoate → 2-keto-3-methylvalerate + H<sub>2</sub>O |
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[[Transamination]] of 2-keto-3-methylvalerate yields isoleucine. |
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== References == |
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{{Reflist}} |
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{{organic-compound-stub}} |
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{{Amino acid metabolism intermediates}} |
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{{DEFAULTSORT:Dihydroxy-3-methylpentanoic acid, 2,3-}} |
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[[Category:Alpha hydroxy acids]] |
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[[Category:Vicinal diols]] |
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[[Category:Beta hydroxy acids]] |
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