Talk:Amlodipine: Difference between revisions
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{{WikiProject Medicine |importance=Mid}} |
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{{Reliable sources for medical articles}} |
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{{User:ClueBot III/ArchiveThis |
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==Question on external links== |
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Hi, I wanted to understand why in external links we can see the manufacturer site and it is not allowed to see an exclusive and informative site about the product like Amlodipine.com. Thanks ([[User:Rmrr|Rmrr]] ([[User talk:Rmrr|talk]]) 11:07, 20 June 2008 (UTC)) |
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==Wiki Education Foundation-supported course assignment== |
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:No response from [[User:CliffC]]? --[[Special:Contributions/99.145.131.169|99.145.131.169]] ([[User talk:99.145.131.169|talk]]) 15:06, 9 October 2008 (UTC) |
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| ⚫ | [[File:Sciences humaines.svg|40px]] This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available [[Wikipedia:Wiki_Ed/University_of_California,_San_Francisco/Words_as_Power_-_Expanding_WikiProject_Pharmacology_(Fall_2015)|on the course page]]. Student editor(s): [[User:LDP02|LDP02]], [[User:Khuynh sf2|Khuynh sf2]], [[User:Amek2|Amek2]], [[User:Csj02|Csj02]]. Peer reviewers: [[User:Irischen1|Irischen1]], [[User:Valerievu1|Valerievu1]], [[User:Phongho1|Phongho1]], [[User:Teebuckles|Teebuckles]]. |
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{{small|Above undated message substituted from [[Template:Dashboard.wikiedu.org assignment]] by [[User:PrimeBOT|PrimeBOT]] ([[User talk:PrimeBOT|talk]]) 10:05, 18 January 2022 (UTC)}} |
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::CliffC and several other editors responded on Rmrr's talk page [http://en.wikipedia.org/wiki/User_talk:Rmrr here] in June. In summary, they told him to stop trying to advertise on Wikipedia and directed him to [[WP:EL]] and [[WP:ADVERT]]. --[[User:CliffC|CliffC]] ([[User talk:CliffC|talk]]) 21:43, 9 October 2008 (UTC) |
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== == |
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Another use of Amlodipine not mentioned in the article is for treatment of headache, often used in conjunction with Amitriptyline. For example, following coratid artery dissection. I haven't added this to the article as I don't know of a citation to give with the added text.[[User:Countercheck|Countercheck]] ([[User talk:Countercheck|talk]]) 19:53, 28 June 2024 (UTC) |
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==Categories== |
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I do not think, that it is necessary to place this article into "Pfizer" category. Actually, not all Amlodipine is Norvasc, there are many other variants of Amlodipine, created by many other pharmaceutical companies--[[User:Армонд|Армонд]]<sup>[[User talk:Армонд|@]]</sup> 17:49, 25 February 2009 (UTC) |
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== A topic of... == |
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[[Amlodipine Besylate]] has been added based on the following |
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http://www.tga.gov.au/docs/pdf/aan/aanchem.pdf |
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--[[Special:Contributions/222.64.18.236|222.64.18.236]] ([[User talk:222.64.18.236|talk]]) 10:41, 21 June 2009 (UTC) |
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http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=A5605|SIGMA&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC |
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--[[Special:Contributions/222.64.18.236|222.64.18.236]] ([[User talk:222.64.18.236|talk]]) 10:43, 21 June 2009 (UTC) |
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== Anyone hear of "amidoipine"? == |
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I have come across this misspelling a few times in the medical field (I am a nursing student) and I wonder if anyone else has, or if anyone has any explanation as to where this jumbling comes from. Is it some type of alternative generic name (as budeprione is to bupropion [Wellbutrin])? Trust me, I have scoured the internet as well as the hospital's online medical library but not yet come across it, so I assume it's some kind of mistake, but would love to hear if there is some other explanation.[[User:Hagenb|Hagenb]] ([[User talk:Hagenb|talk]]) 00:09, 1 December 2009 (UTC) |
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==Stereochemistry== |
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Just wanted to note that I could not determine, looking at the IUPAC name and the image of the chemicals formula, I only saw 1 stereocenter, yet the IUPAC name shows 2; in addition, the stereocenter I thought I had picked out correctly didn't fit with any of the possible numbering schemes. Because chemistry is an important aspect of pharmaceutical articles and is all too often ignored, I'd really like to see something explaining this. If it weren't important, there wouldn't be the epithet of 'racemate;' methadone is a racemate, but its stereochemistry is not discussed very much because it's only available as racemate and studies with the pure isomers are few, due to the expense and relatively small benefit in isolating a racemate's constituents. Not like it'll happen before I die, in all seriousness; but hopefully this message might indirectly help a future visitor, if only a tiny bit. To recap: someone with the appropriate knowledge would be doing WP and its denizens a service to add even a little bit on that issue here. At the very least, it needs to be cleared up whether there are 1 or 2 stereocenters as well as which carbons they are located on; this could be done by modifying the image to show the resonance differently, or something.. I dunno. Too many words already for something that might never be read. [[User:Mr0t1633|Mr0t1633]] ([[User talk:Mr0t1633|talk]]) 20:13, 10 December 2009 (UTC) |
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:Moin, moin, Mr0t1633, I agree 100%. The practical importance of stereochemistry is presently underestimated at Wikipedia quite ofton. The different biological/pharmacological behavior of enantiomers is obvious/normal/a rule. Best regards, --[[User:Jü|Jü]] ([[User talk:Jü|talk]]) 22:16, 10 December 2009 (UTC) |
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The compound has one chiral centre (the 4-position of the dihydropyridine ring, where the 2-chlorophenyl substituent is attached). This is clearly mentioned in the article under "Stereoisomerism". The IUPAC name clearly indicates that the drug is a racemate (RS). I don't know, but I guess that the biological activity of the separate enantiomers has been determined. [[Special:Contributions/93.191.24.30|93.191.24.30]] ([[User talk:93.191.24.30|talk]]) 09:54, 30 January 2014 (UTC) Philip Jewess. |
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== Copyright violation !!== |
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See please http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=22972 "Mechanism of Action" and more [[User:Nini00|Nini00]] ([[User talk:Nini00|talk]]) 20:03, 8 December 2012 (UTC) |
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'''This is not a copyright violation.''' '''Unless otherwise noted, everything at nih.gov is public domain''', as stated on the copyright page, which is linked from the main page (it's at the bottom). To wit: |
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NLM Copyright Information |
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'''Government information at NLM Web sites is in the public domain.''' Public domain information may be freely distributed and copied <span style="font-size: smaller;" class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/71.168.81.181|71.168.81.181]] ([[User talk:71.168.81.181|talk]]) 23:30, 2 January 2014 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot--> |
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==Can the article be updated if cross-reactions with grapefruit-juice are credible?== |
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I'm not qualified to judge what is said here: |
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http://www.cmaj.ca/content/suppl/2012/11/26/cmaj.120951.DC1/grape-bailey-1-at.pdf |
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and |
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http://well.blogs.nytimes.com/2012/12/17/grapefruit-is-a-culprit-in-more-drug-reactions/ |
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but if the above are credible can someone update this Wikipedia article with this information?[[Special:Contributions/76.8.67.2|76.8.67.2]] ([[User talk:76.8.67.2|talk]]) 09:05, 6 January 2013 (UTC)Christopher L. Simpson |
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== Clarification of elimination from the body == |
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In the interactions section, CYP3A4 as the pathway for metabolization, but in Pharmacokinetics and metabolism section, it's mentioned that 60% of the drug is recovered in the urine. Is elimination from the body primarily liver driven or renal driven?[[User:Wzrd1|Wzrd1]] ([[User talk:Wzrd1|talk]]) 00:49, 6 July 2013 (UTC) |
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== Correction Needed == |
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The author claims that there are no DHPR L-type Calcium channels on the heart muscles. Heart muscles release extracellular calcium into the sarcolemma through dihydropyridine receptor channels, which couples with ryanodine receptors on the Sarcoplasm Reticulum to release more calcium in the sarcolemma. Please refer to this article: Katoh H, Schlotthauer K, Bers DM. Transmission of information from cardiac dihydropyridine receptor to ryanodine receptor: evidence from BayK 8644 effects on resting Ca(2+) sparks. Circ Res. 2000 Jul 21;87(2):106-11. PubMed PMID: 10903993. <small><span class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Alizargar|Alizargar]] ([[User talk:Alizargar|talk]] • [[Special:Contributions/Alizargar|contribs]]) 01:12, 24 October 2013 (UTC)</span></small><!-- Template:Unsigned --> <!--Autosigned by SineBot--> |
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== FDA Plagiarism == |
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There is unquoted and unattributed text taken from the FDA in this article (see [[Wikipedia:Plagiarism#Copying material from free sources]]) on need for attribution or re-phrasing of text lifted from a free source). I am unable to find an FDA attribution template, indeed, locating the templates for this kind of situation is a challenge. [[User:SandyGeorgia|'''Sandy'''<font color="green">Georgia</font>]] ([[User talk:SandyGeorgia|Talk]]) 13:16, 22 November 2014 (UTC) |
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== Edits made by LDP02 == |
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We attempted to improve to clarify the medical use section. |
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We split contraindications into absolute and relative. |
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We organized adverse effects into dose-related, non dose-related, and rare and added percentages. |
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We expanded the drug-drug interaction section. |
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We added an overdose section. |
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[[User:LDP02|LDP02]] ([[User talk:LDP02|talk]]) 21:43, 6 November 2015 (UTC) <small><span class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:LDP02|LDP02]] ([[User talk:LDP02|talk]] • [[Special:Contributions/LDP02|contribs]]) 19:11, 5 November 2015 (UTC)</span></small><!-- Template:Unsigned --> <!--Autosigned by SineBot--> |
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==Irischen1 peer review of edits made by LDP02 == |
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They made good edits to the adverse events, prioritizing common vs. rare adverse events. They also added an interactions section but should add some commonly used 3A4 inhibitors. They should consider rewriting the mechanism of action section so that uses more lay language. |
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Latest revision as of 21:59, 28 June 2024
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Wiki Education Foundation-supported course assignment
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Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 10:05, 18 January 2022 (UTC)
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Another use of Amlodipine not mentioned in the article is for treatment of headache, often used in conjunction with Amitriptyline. For example, following coratid artery dissection. I haven't added this to the article as I don't know of a citation to give with the added text.Countercheck (talk) 19:53, 28 June 2024 (UTC)
- will look--Ozzie10aaaa (talk) 21:59, 28 June 2024 (UTC)