Talk:Xylazine

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Fixed link in article. DferDaisy (talk) 02:41, 31 January 2017 (UTC)

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Unreliable citation in Pharmacodynamics?

I was interested in learning more about the following claim from the article:

Xylazine has varying affinities for cholinergic, serotonergic, dopaminergic, α1 adrenergic, H2-histaminergic and opiate receptors.[4]

Unfortunately I wasn't able to verify this from the citation. It seems the claim has been repeated almost verbatim in a series of papers, all ultimately relying on a source from 1982 which I was unable to locate.

The wiki citation (Ruiz-Colón et al, 2014) mentions these receptors only once in the introduction:

Its actions may also involve cholinergic, serotonergic, dopaminergic, α-1-adrenergic, histaminergic, or opiate mechanisms [3].

The citation here is Hoffmann et al, 2001 which almost identically states:

Xylazine actions may also involve cholinergic, serotonergic, dopaminergic, α1-adrenergic, histaminergic, or opiate mechanisms (12).

Which leads to the citation I wasn't able to find:

J.V. Kitzman, N.H. Booth, and R.C. Hatch. Antagonism of xylazine sedation by 4-aminopyridine and yohimbine in cattle. Am. J. Vet. Res. 43:2165-2169 (1982)

I also searched pubchem which has 2,275 bioassays for xylazine. Despite this I found only:

• Inactive at Serotonin 1A, 2A, 5A
• Inactive at Dopamine D1, D2, D3
• Inactive at α1 adrenergic

No conclusion can be drawn about the original claim's veracity, but given the context and general lack of information I wonder if:

• The primary source may have demonstrated partial reversal of xylazine's effects, and speculated that the remaining effects are due to an unknown mechanism (perhaps cholinergic, serotonergic, dopaminergic, etc).
• This was misquoted by a citing author as evidence of a secondary mechanism, and this misquote was cited by all subsequent papers.

I'd be interested if anyone is aware of another source for these claims, or more detailed information on xylazine's activity in general. Jamedeus (talk) 09:26, 9 January 2023 (UTC)

FDA should immediately ban this drug.

This chemical is causing havoc and taking young lives. FDA should ban it immediately and search for any traces left in any corner of any country. WikiEditorZairrahMurtazaRizvi (talk) 04:34, 25 February 2023 (UTC)

Are you saying the DEA should schedule it?

Because it clearly has veterinary uses. 108.60.63.241 (talk) 14:14, 23 March 2023 (UTC)

This talk page is not a place for discussing that. WPEditor42 (talk • contribs) 12:12, 24 March 2023 (UTC)

Inappropriate reference to animal study

Ref name=Xiao is to an animal study, strictly confined to monkeys, of hyperglycemia following xylazine injection. Other properties, uses and side effects are mentioned, but this paper is not itself a review of the drug in general, or a review of human use. Xylazine is much in the news currently, so most users reading this article are likely interested in human (ab)use, rather than legitimate veterinary usage. This cite should be replaced in most cases by a more appropriate one, or state clearly that it is only an animal study.

There are half a dozen references to this source scattered through the article; the first cite is in the lead and explicitly ties it to humans, so that one definitely needs to be fixed. It looks a bit complicated to review them all, find a better reference, and redact. I will do the clean-up if another editor doesn't jump in first, but I'll have to postpone it. D Anthony Patriarche (talk) 16:15, 31 March 2023 (UTC)