Propantheline bromide: Difference between revisions
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==Adverse effects== |
==Adverse effects== |
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[[Adverse drug reaction|Side effects]] include [[tachycardia]], [[constipation]], [[photophobia|hypersensitivity to light]], dry mouth, and [[urinary retention]]. |
[[Adverse drug reaction|Side effects]] include [[tachycardia]], [[constipation]], [[photophobia|hypersensitivity to light]], dry mouth, and [[urinary retention]]. |
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This can also be prescribed by dentists for certain patients who salivate excessively. By giving this medication it becomes easier to do "dry" dentistry |
This can also be prescribed by dentists for certain patients who salivate excessively. By giving this medication it becomes easier to do "dry" dentistry. |
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==Mechanism of action== |
==Mechanism of action== |
Revision as of 02:57, 12 June 2019
This article needs additional citations for verification. (March 2009) |
Clinical data | |
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AHFS/Drugs.com | Monograph |
MedlinePlus | a684020 |
ATC code | |
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CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.000.028 |
Chemical and physical data | |
Formula | C23H30NO3 |
Molar mass | 368.489 g/mol g·mol−1 |
3D model (JSmol) | |
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(what is this?) (verify) |
Propantheline bromide (INN) is an antimuscarinic agent used for the treatment of excessive sweating (hyperhidrosis), cramps or spasms of the stomach, intestines (gut) or bladder, and involuntary urination (enuresis). It can also be used to control the symptoms of irritable bowel syndrome and similar conditions. This agent can also be used for patients who experience intense GI symptoms while tapering off of TCAs. [1]
Indications
By relaxing the gut muscle, propantheline can relieve pain in conditions caused by spasm of the muscle in the gut. Relaxing the smooth muscle in the bladder prevents the involuntary spasms that can allow leakage of urine from the bladder in the condition known as enuresis (involuntary urination in adults). Propantheline can also be used to treat excessive sweating because acetylcholine block also reduces secretions such as sweat and tears.
Adverse effects
Side effects include tachycardia, constipation, hypersensitivity to light, dry mouth, and urinary retention. This can also be prescribed by dentists for certain patients who salivate excessively. By giving this medication it becomes easier to do "dry" dentistry.
Mechanism of action
Propantheline is one of a group of antispasmodic medications which work by blocking the action of the chemical messenger acetylcholine, which is produced by nerve cells, to muscarinic receptors present in various smooth muscular tissues, in places such as the gut, bladder and eye. Normally, the binding of acetylcholine induces involuntary smooth muscular contractions.
References
- ^ Vasavada, Sandip P.; Appell, Rodney; Sand, Peter K.; Raz, Shlomo (2004). Female Urology, Urogynecology, and Voiding Dysfunction. Informa Health Care. ISBN 0-8247-5426-3.