Propantheline bromide: Difference between revisions
m Bot: Migrating 2 interwiki links, now provided by Wikidata on d:q3275451 |
m WP:CHECKWIKI error fixes using AWB (9615) |
||
| Line 47: | Line 47: | ||
}} |
}} |
||
'''Propantheline bromide''' ([[International Nonproprietary Name|INN]]) is an [[antimuscarinic]] agent used for the treatment of excessive sweating ([[hyperhidrosis]]), cramps or spasms of the stomach, intestines (gut) or bladder, and involuntary urination ([[enuresis]]). It can also be used to control the symptoms of [[irritable bowel syndrome]] and similar conditions. This agent can also be used for patients who experience intense GI symptoms while tapering off of [[Tricyclic antidepressant|TCAs]]. |
'''Propantheline bromide''' ([[International Nonproprietary Name|INN]]) is an [[antimuscarinic]] agent used for the treatment of excessive sweating ([[hyperhidrosis]]), cramps or spasms of the stomach, intestines (gut) or bladder, and involuntary urination ([[enuresis]]). It can also be used to control the symptoms of [[irritable bowel syndrome]] and similar conditions. This agent can also be used for patients who experience intense GI symptoms while tapering off of [[Tricyclic antidepressant|TCAs]]. |
||
<ref>{{ |
<ref>{{cite book|title=Female Urology, Urogynecology, and Voiding Dysfunction|first1= Sandip P.|last1= Vasavada|first2= Rodney|last2= Appell|first3= Peter K.|last3= Sand|first4= Shlomo|last4= Raz|publisher=Informa Health Care|year= 2004|ISBN=0-8247-5426-3}}</ref> |
||
==Indications== |
==Indications== |
||
| Line 60: | Line 60: | ||
==References== |
==References== |
||
{{ |
{{reflist}} |
||
{{Drugs for functional gastrointestinal disorders}} |
{{Drugs for functional gastrointestinal disorders}} |
||
Revision as of 23:57, 8 November 2013
 | This article needs additional citations for verification. (March 2009) |
{{Drugbox | Verifiedfields = changed | verifiedrevid = 464216255 | IUPAC_name = N-isopropyl-N-methyl-N-{2-[(9H-xanthen-9-ylcarbonyl)oxy]ethyl}propan-2-aminium bromide | image = Proprantheline bromide.svg
| tradename = | Drugs.com = Monograph | MedlinePlus = a684020 | pregnancy_AU = | pregnancy_US = | legal_AU = | legal_UK = | legal_US =
| CASNo_Ref = 
| DrugBank = DB00782
| ChemSpiderID_Ref =
| C=23 | H=30 | N=1 | O=3
| molecular_weight = 368.489 g/mol
| smiles = [Br-].O=C(OCC[N+](C(C)C)(C(C)C)C)C2c3c(Oc1c2cccc1)cccc3
| InChI = 1/C23H30NO3.BrH/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22;/h6-13,16-17,22H,14-15H2,1-5H3;1H/q+1;/p-1
| InChIKey = XLBIBBZXLMYSFF-REWHXWOFAD
| StdInChI_Ref =
Indications
By relaxing the gut muscle, propantheline can relieve pain in conditions caused by spasm of the muscle in the gut. Relaxing the smooth muscle in the bladder prevents the involuntary spasms that can allow leakage of urine from the bladder in the condition known as enuresis (involuntary urination in adults). Propantheline can also be used to treat excessive sweating because acetylcholine block also reduces secretions such as sweat and tears.
Adverse effects
Side effects include tachycardia, constipation, hypersensitivity to light, dry mouth, and urinary retention. This can also be prescribed by dentists for certain patients who salivate excessively. By taking this medication it becomes easier to do "dry" dentistry
Mechanism of action
Propantheline is one of a group of antispasmodic medications which work by blocking the action of the chemical messenger acetylcholine, which is produced by nerve cells, to muscarinic receptors present in various smooth muscular tissues, in places such as the gut, bladder and eye. Normally, the binding of acetylcholine induces involuntary smooth muscular contractions.
References
- ^ Vasavada, Sandip P.; Appell, Rodney; Sand, Peter K.; Raz, Shlomo (2004). Female Urology, Urogynecology, and Voiding Dysfunction. Informa Health Care. ISBN 0-8247-5426-3.
 | This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it. |