S-Adenosyl-L-homocysteine: Difference between revisions
Appearance
Content deleted Content added
rephrase |
url |
||
Line 48: | Line 48: | ||
}} |
}} |
||
'''''S''-Adenosyl-<small>L</small>-homocysteine''' ('''SAH''') is the biosynthetic precursor to [[homocysteine]].<ref>{{cite journal|author=Finkelstein, J. D.|year=2000|title=Pathways and regulation of homocysteine metabolism in mammals|journal=Semin. Thromb. Hemost.|volume=26|page=219–225| |
'''''S''-Adenosyl-<small>L</small>-homocysteine''' ('''SAH''') is the biosynthetic precursor to [[homocysteine]].<ref>{{cite journal|author=Finkelstein, J. D.|year=2000|title=Pathways and regulation of homocysteine metabolism in mammals|journal=Semin. Thromb. Hemost.|volume=26|page=219–225|url=https://www.thieme-connect.com/products/ejournals/html/10.1055/s-2000-8466}}</ref> SAH is formed by the [[demethylation]] of [[S-Adenosyl methionine|''S''-adenosyl-<small>L</small>-methionine]].<ref>{{cite journal|author=Ribbe, M. W.; Hu, Y.; Hodgson, K. O.; Hedman, B.|title=Biosynthesis of Nitrogenase Metalloclusters|journal=Chem. Rev.|year=2014|volume=114|pages=4063-4080|doi=10.1021/cr400463x}}</ref><ref>{{cite journal|url=https://academic.oup.com/jn/article/132/8/2361S/4687579|doi=10.1093/jn/132.8.2361S|pmid=12163693|title=Elevation in S-Adenosylhomocysteine and DNA Hypomethylation: Potential Epigenetic Mechanism for Homocysteine-Related Pathology|journal=The Journal of Nutrition|volume=132|issue=8|pages=2361S–2366S|year=2002|last1=James|first1=S. Jill|last2=Melnyk|first2=Stepan|last3=Pogribna|first3=Marta|last4=Pogribny|first4=Igor P|last5=Caudill|first5=Marie A}}</ref> [[Adenosylhomocysteinase]] converts SAH into homocysteine and adenosine. |
||
==References== |
==References== |
Revision as of 11:37, 23 April 2019
Names | |
---|---|
IUPAC name
S-(5'-Deoxyadenos-5'-yl)-L-homocysteine
| |
Other names
AdoHcy, 2-S-adenosyl-L-homocysteine,
5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine S-adenosylhomocysteine, SAH | |
Identifiers | |
3D model (JSmol)
|
|
ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.012.328 |
KEGG | |
MeSH | S-Adenosylhomocysteine |
PubChem CID
|
|
CompTox Dashboard (EPA)
|
|
| |
| |
Properties | |
C14H20N6O5S | |
Molar mass | 384.412 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
S-Adenosyl-L-homocysteine (SAH) is the biosynthetic precursor to homocysteine.[1] SAH is formed by the demethylation of S-adenosyl-L-methionine.[2][3] Adenosylhomocysteinase converts SAH into homocysteine and adenosine.
References
- ^ Finkelstein, J. D. (2000). "Pathways and regulation of homocysteine metabolism in mammals". Semin. Thromb. Hemost. 26: 219–225.
- ^ Ribbe, M. W.; Hu, Y.; Hodgson, K. O.; Hedman, B. (2014). "Biosynthesis of Nitrogenase Metalloclusters". Chem. Rev. 114: 4063–4080. doi:10.1021/cr400463x.
{{cite journal}}
: CS1 maint: multiple names: authors list (link) - ^ James, S. Jill; Melnyk, Stepan; Pogribna, Marta; Pogribny, Igor P; Caudill, Marie A (2002). "Elevation in S-Adenosylhomocysteine and DNA Hypomethylation: Potential Epigenetic Mechanism for Homocysteine-Related Pathology". The Journal of Nutrition. 132 (8): 2361S–2366S. doi:10.1093/jn/132.8.2361S. PMID 12163693.